Article

A benchmark of DNA methylation deconvolution methods for tumoral fraction estimation using DecoNFlow

2025-11-27

Abstract excerpt

In cancer patients, circulating cell-free DNA (cfDNA) is released into body fluids from both healthy and cancer cells. The proportion of tumor-derived cfDNA serves as a surrogate marker of tumor burden allowing disease monitoring. Tumoral cfDNA can be distinguished based on patient specific tumoral mutations or using more general tumor specific DNA methylation patterns, that are preserved on tumoral cfDNA. DNAm pr...

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Literature Corpus work: b9edab66-abf7-590f-9bcd-b4835a04d73f
DOI: 10.1101/2025.11.27.688590

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