Back to search

Article

Human whole-epigenome modelling for clinical applications with Pleiades

2025-07-21

Abstract excerpt

Gene regulation in humans extends beyond the four-letter genetic code. DNA methylation, in particular, functions as a critical epigenetic regulator, dynamically programming cellular identity, adapting gene expression in response to environmental cues, and underpinning the onset and progression of numerous diseases. Here we present Pleiades, a series of whole-genome epigenetic foundation models spanning three sizes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e65cdee7-b7bf-54b7-9134-907a0560c755
DOI
10.1101/2025.07.16.665231
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Human whole-epigenome modelling for clinical applications with PleiadesDOI 10.1101/2025.07.16.665231
MethylGPT: a foundation model for the DNA methylomeSemantic proximity
CpGPT: a Foundation Model for DNA MethylationSemantic proximity
Human panepigenome represents epigenomic diversitySemantic proximity
Melody: Decoding the Sequence Determinants of Locus Specific DNA Methylation Across Human TissuesSemantic proximity
MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Network, Inspired by Capsule NetworksSemantic proximity
MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks.Semantic proximity
scDNAm-GPT Captures Genome-wide CpG Dependencies in Single-cell DNA methylomes to Revolutionize Epigenetic AnalysisSemantic proximity
Getting Personal with Epigenetics: Towards Machine-Learning-Assisted Precision EpigenomicsSemantic proximity
VariantFormer: A hierarchical transformer integrating DNA sequences with genetic variations and regulatory landscapes for personalized gene expression predictionSemantic proximity
Dissecting sequence determinants of DNA methylation and in silico perturbationSemantic proximity
A New Paradigm for Genome-wide DNA Methylation Prediction Without Methylation InputSemantic proximity
System-level health profiling from blood DNA methylation with explainable deep learningSemantic proximity
Select a neighboring publication to make it the new centre.