Article

Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancer

2022-06-15

Abstract excerpt

<h4>ABSTRACT</h4> Activating estrogen receptor alpha (ER) mutations are present in primary endometrial and metastatic breast cancers, promoting estrogen-independent activation of the receptor. Functional characterizations in breast cancer have established unique molecular and phenotypic consequences of the receptor, yet the impact of ER mutations in endometrial cancer has not been fully explored. In this study, w...

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Literature Corpus work: ab9f4121-0220-59a5-ab51-0c8f0b936ca5
DOI: 10.1101/2022.06.13.495977

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