Article

Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and secondary effects

2020-04-09

Abstract excerpt

While breast cancer patients with tumors that express estrogen receptor α (ER) generally respond well to hormone therapies that block ER activity, a significant number of patients relapse. Approximately 30% of these recurrences harbor activating mutations in the ligand binding domain (LBD) of ER, which have been shown to confer ligand-independent function. However, much is still unclear regarding the effect of mut...

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Literature Corpus work: 3f8419a3-83c1-5a91-98e2-3285bd595937
DOI: 10.1101/2020.04.08.032169

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