Article
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Genome research - 1 Nov 2012
Liang Han, Cheung Lydia W T, Li Jie, Ju Zhenlin, Yu Shuangxing, Stemke-Hale Katherine, Dogruluk Turgut, Lu Yiling, Liu Xiuping, Gu Chao, Guo Wei, Scherer Steven E, Carter Hannah, Westin Shannon N, Dyer Mary D, Verhaak Roeland G W, Zhang Fan, Karchin Rachel, Liu Chang-Gong, Lu Karen H, Broaddus Russell R, Scott Kenneth L, Hennessy Bryan T, Mills Gordon B
Abstract excerpt
Endometrial cancer is the most common gynecological malignancy, with more than 280,000 cases occurring annually worldwide. Although previous studies have identified important common somatic mutations in endometrial cancer, they have primarily focused on a small set of known cancer genes and have thus provided a limited view of the molecular basis underlying this disease. Here we have developed an integrated...
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