Article
Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha-Mutant Endometrial Cancer.
Molecular cancer research : MCR - 2 Oct 2023
Blanchard Zannel, Rush Craig M, Arnesen Spencer, Vahrenkamp Jeffery M, Rodriguez Adriana C, Jarboe Elke A, Brown Callie, Chang Matthew E K, Flory Mark R, Mohammed Hisham, Modzelewska Katarzyna, Lum David H, Gertz Jason
Abstract excerpt
Activating estrogen receptor alpha (ER; also known as ESR1) mutations are present in primary endometrial and metastatic breast cancers, promoting estrogen-independent activation of the receptor. Functional characterizations in breast cancer have established unique molecular and phenotypic consequences of the receptor, yet the impact of ER mutations in endometrial cancer has not been fully explored. In this study,...
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