Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities

Abstract excerpt

<title>Abstract</title> <p>Endometrial carcinoma (EC), the most common gynecologic cancer type, encompasses multiple molecular subtypes that have consistent prognostic values and are being adopted in clinical practice to guide treatment decisions. However, it remains unclear whether each of these molecular subtypes have unique therapeutic vulnerabilities that can be exploited for advancing the management of ECs....

Topics

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• Aged, 80 and over
• Cancer Genomics and Diagnostics
• Cystadenocarcinoma, Serous
• DNA Copy Number Variations
• Endometrial Neoplasms
• F-Box-WD Repeat-Containing Protein 7
• Genomic Instability
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

ca6ee4be-f2ec-5fa4-ab24-615ee2a2463e

DOI

10.21203/rs.3.rs-6536216/v1