Article
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.
Nature genetics - 1 Dec 2012
Le Gallo Matthieu, O'Hara Andrea J, Rudd Meghan L, Urick Mary Ellen, Hansen Nancy F, O'Neil Nigel J, Price Jessica C, Zhang Suiyuan, England Bryant M, Godwin Andrew K, Sgroi Dennis C, Hieter Philip, Mullikin James C, Merino Maria J, Bell Daphne W
Abstract excerpt
Endometrial cancer is the sixth most commonly diagnosed cancer in women worldwide, causing ~74,000 deaths annually. Serous endometrial cancers are a clinically aggressive subtype with a poorly defined genetic etiology. We used whole-exome sequencing to comprehensively search for somatic mutations within ~22,000 protein-encoding genes in 13 primary serous endometrial tumors. We subsequently resequenced 18 genes,...
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