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Article

Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects.

Cancer research - 1 Feb 2021

Arnesen Spencer, Blanchard Zannel, Williams Michelle M, Berrett Kristofer C, Li Zheqi, Oesterreich Steffi, Richer Jennifer K, Gertz Jason

Abstract excerpt

While breast cancer patients with tumors that express estrogen receptor α (ER) generally respond well to hormone therapies that block ER activity, a significant number of patients relapse. Approximately 30% of these recurrences harbor activating mutations in the ligand binding domain (LBD) of ER, which have been shown to confer ligand-independent function. However, much is still unclear regarding the effect of...

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Identifiers

PMID: 33184109
DOI: 10.1158/0008-5472.CAN-20-1171
PMCID: PMC7854489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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