Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer.

doi:10.1101/gr.244780.118

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Article

Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer.

Genome research - 1 Sept 2019

Blanchard Zannel, Vahrenkamp Jeffery M, Berrett Kristofer C, Arnesen Spencer, Gertz Jason

Abstract excerpt

Estrogen receptor 1 (ESR1) mutations have been identified in hormone therapy-resistant breast cancer and primary endometrial cancer. Analyses in breast cancer suggest that mutant ESR1 exhibits estrogen-independent activity. In endometrial cancer, ESR1 mutations are associated with worse outcomes and less obesity, however, experimental investigation of these mutations has not been performed. Using a unique...

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Topics

CRISPR-Cas Systems
Cell Line, Tumor
Cell Movement
Cell Proliferation
Endometrial Neoplasms
Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Estrogens

Female

Gene Expression Profiling

Gene Expression Regulation, Neoplastic

Gene Regulatory Networks

Humans

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 31362937
DOI: 10.1101/gr.244780.118
PMCID: PMC6724674

Genes

ESR1

Provenance

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