Article
Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models.
Breast cancer research : BCR - 23 May 2017
Bahreini Amir, Li Zheqi, Wang Peilu, Levine Kevin M, Tasdemir Nilgun, Cao Lan, Weir Hazel M, Puhalla Shannon L, Davidson Nancy E, Stern Andrew M, Chu David, Park Ben Ho, Lee Adrian V, Oesterreich Steffi
Abstract excerpt
BACKGROUND: Mutations in the estrogen receptor alpha (ERα) 1 gene (ESR1) are frequently detected in ER+ metastatic breast cancer, and there is increasing evidence that these mutations confer endocrine resistance in breast cancer patients with advanced disease. However, their functional role is not well-understood, at least in part due to a lack of ESR1 mutant models. Here, we describe the generation and...
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