Article

Sen1 is required for RNA Polymerase III transcription termination in an R-loop independent manner

2019-03-11

Abstract excerpt

<h4>ABSTRACT</h4> R-loop disassembly by the human helicase Senataxin contributes to genome stability and to proper transcription termination at a subset of RNA polymerase II genes. Whether Senataxin-mediated R-loop disassembly also contributes to transcription termination at other classes of genes has remained unclear. Here we show in fission yeast that Senataxin Sen1 promotes efficient termination of RNA Polyme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab35e77b-9b50-56fc-83dc-027ba2c735ab
DOI: 10.1101/571737

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sen1 is required for RNA Polymerase III transcription termination in an R-loop independent mannerDOI 10.1101/571737Read

Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factorSemantic proximity Read

Kinetic competition between RNA Polymerase II and Sen1-dependent transcription termination.Semantic proximity Read

Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.Semantic proximity Read

Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration.Semantic proximity Read

Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription.Semantic proximity Read

Unwinding the role of senataxin in neurodegeneration.Semantic proximity Read

Sen1p performs two genetically separable functions in transcription and processing of U5 small nuclear RNA in Saccharomyces cerevisiae.Semantic proximity Read

H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.Semantic proximity Read

RNA dysregulation and compromised neuronal identity drive pathogenesis in Senataxin-associated ALSSemantic proximity Read

Role of Senataxin in Amyotrophic Lateral Sclerosis.Semantic proximity Read

Sae2/CtIP prevents R-loop accumulation in eukaryotic cellsSemantic proximity Read

The Ess1 prolyl isomerase is required for transcription termination of small noncoding RNAs via the Nrd1 pathway.Semantic proximity Read