Article

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

2018-08-17

Abstract excerpt

The Sae2/CtIP protein is required for efficient processing of DNA double-strand breaks that initiate homologous recombination in eukaryotic cells. Sae2/CtIP is also important for survival of single-stranded Top1-induced lesions and CtIP is known to associate directly with transcription-associated complexes in mammalian cells. Here we investigate the role of Sae2/CtIP at single-strand lesions in budding yeast and i...

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Literature Corpus work: 665118dc-2275-5b62-9dc9-1f091fe2c406
DOI: 10.1101/394924

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