Article

RNA dysregulation and compromised neuronal identity drive pathogenesis in Senataxin-associated ALS

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> RNA dysregulation is a recognized contributor to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), the most common motor neuron (MN) disease. However, the molecular mechanisms linking defects in RNA metabolism to selective neuronal vulnerability remain poorly understood. Alterations in the cellular levels of R-loops –structures forming by reannealing of the nascent RNA with...

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Literature Corpus work: 48e0c933-9583-5bd5-a0e9-98ffe6c74630
DOI: 10.64898/2026.06.30.735532

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