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Article

H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.

Molecular and cellular biology - 1 Sept 2011

Terzi Nihal, Churchman L Stirling, Vasiljeva Lidia, Weissman Jonathan, Buratowski Stephen

Abstract excerpt

In Saccharomyces cerevisiae, the Nrd1-Nab3-Sen1 pathway mediates the termination of snoRNAs and cryptic unstable transcripts (CUTs). Both Nrd1 and the Set1 histone H3K4 methyltransferase complex interact with RNA polymerase II (Pol II) during early elongation, leading us to test whether these two processes are functionally linked. The deletion of SET1 exacerbates the growth rate and termination defects of nrd1...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21709022
DOI: 10.1128/MCB.05590-11
PMCID: PMC3165552

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