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Article

Role of Senataxin in Amyotrophic Lateral Sclerosis.

Journal of molecular neuroscience : MN - 1 Dec 2023

Tsui Andrew, Kouznetsova Valentina L, Kesari Santosh, Fiala Milan, Tsigelny Igor F

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive, uncurable neurodegenerative disorder characterized by the degradation of motor neurons leading to muscle impairment, failure, and death. Senataxin, encoded by the SETX gene, is a human helicase protein whose mutations have been linked with ALS onset, particularly in its juvenile ALS4 form. Using senataxin's yeast homolog Sen1 as a model for study, it is...

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PMID: 37982993
DOI: 10.1007/s12031-023-02169-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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