Article
The Ess1 prolyl isomerase is required for transcription termination of small noncoding RNAs via the Nrd1 pathway.
Molecular cell - 23 Oct 2009
Singh Navjot, Ma Zhuo, Gemmill Trent, Wu Xiaoyun, Defiglio Holland, Rossettini Anne, Rabeler Christina, Beane Olivia, Morse Randall H, Palumbo Michael J, Hanes Steven D
Abstract excerpt
Genome-wide studies have identified abundant small, noncoding RNAs, including small nuclear RNAs, small nucleolar RNAs (snoRNAs), cryptic unstable transcripts (CUTs), and upstream regulatory RNAs (uRNAs), that are transcribed by RNA polymerase II (pol II) and terminated by an Nrd1-dependent pathway. Here, we show that the prolyl isomerase Ess1 is required for Nrd1-dependent termination of noncoding RNAs. Ess1...
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