Article
Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription.
Nucleic acids research - 16 Feb 2018
Brambati Alessandra, Zardoni Luca, Achar Yathish Jagadheesh, Piccini Daniele, Galanti Lorenzo, Colosio Arianna, Foiani Marco, Liberi Giordano
Abstract excerpt
The yeast RNA/DNA helicase Sen1, Senataxin in human, preserves the integrity of replication forks encountering transcription by removing RNA-DNA hybrids. Here we show that, in sen1 mutants, when a replication fork clashes head-on with transcription is arrested and, as a consequence, the progression of the sister fork moving in the opposite direction within the same replicon is also impaired. Therefore, sister...
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