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A Dock8-dependent mechanosensitive central actin pool maintains T cell shape and protects the nucleus during migration

26 Jun 2025

Abstract excerpt

Immune cells navigate through complex tissue architectures by extensive cellular deformation, low adhesion, and high cell velocities. Loss-of-function mutations in dedicator of cytokinesis 8 ( Dock8 ) are associated with immunodeficiency as immune cells becoming entangled during migration through dense environments, but their migration on two-dimensional surfaces remains entirely intact. Here, we investigated the...

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PMID: 40570086
DOI: 10.1126/sciimmunol.adt9239

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