Article

DOCK8 regulates a mechanosensitive actin redistribution that maintains immune cell cohesion and protects the nucleus during migration

2024-07-26

Abstract excerpt

Immune cells navigate through complex 3-dimensional tissue architectures, utilizing an amoeboid mode of migration, characterized by extensive cellular deformation, low adhesion, and high cell velocities. In the absence of expression of Dedicator of Cytokinesis 8 (Dock8) , a gene identified with loss-of-function mutations in immunodeficiency, cells become entangled during migration through dense, confined environm...

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Literature Corpus work: 81f35494-c63d-5e74-a33e-15235fadfbd0
DOI: 10.1101/2024.07.26.605273

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