Article

Loss of <i>Sun2</i> ablates nuclear mechanosensing-driven extracellular matrix production and mitigates lung fibrosis

2026-03-20

Abstract excerpt

Fibrosis and pathological stiffening of tissue are driven by mechanical and biochemical signaling pathways. Here, we find that Sun2, an integral inner nuclear membrane component of Linker of Nucleoskeleton and Cytoskeleton (LINC) complexes, is up-regulated in the lung of patients suffering from fibrotic conditions and in fibroblasts during an injury-induced mouse model of lung fibrosis. Sun2 protein levels also in...

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Literature Corpus work: 228a64f0-2f40-5373-a2ef-e317fb02c39b
DOI: 10.64898/2026.03.18.712778

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