Article

The Heterotaxy Gene <i>CCDC11</i> is Essential for Cytokinesis and Cell-Cell Adhesion via RhoA Regulation

2018-10-24

Abstract excerpt

<h4>SUMMARY</h4> Mutations in CCDC11 have been identified in multiple patients with heterotaxy (Htx), a disorder of left-right (LR) patterning of the internal organs. In Xenopus , depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, normally monociliated cells of the Left-Right Organizer (LRO) exhibit multiple cilia per cell. Unexpectedly, we found tha...

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Literature Corpus work: bf36aa57-5b48-5851-94e1-d11ff410ed02
DOI: 10.1101/452631

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