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Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stress

2026-01-21

Abstract excerpt

<h4>Summary</h4> Invasively migrating cells thread their nucleus through confined interstitial spaces. How cells protect the nucleus from intracellular forces is poorly understood. Here, we show that the septin cytoskeleton buffers the actomyosin forces that power nuclear movement. Septin filaments comprising SEPT9, a septin amplified in breast cancer, align with perinuclear actomyosin cables which exhibit higher...

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Literature Corpus work
1f037f6a-5af1-51a0-a169-a043a2096177
DOI
10.64898/2026.01.21.700789
Open publication

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Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stressDOI 10.64898/2026.01.21.700789
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