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Cytoskeletal and Cell Adhesion Defects in Wounded and<i>Pax6</i><sup>+/−</sup>Corneal Epithelia

26 Feb 2010

Abstract excerpt

PURPOSE: PAX6 heterozygosity (PAX6(+/-)) causes aniridia and aniridia-related keratopathy (ARK) in humans, but the pathway from gene dosage deficiency to clinical disease has not been fully characterized. Recently, the authors suggested a model of a chronic wound state exacerbated by oxidative stress, showed the barrier function of Pax6(+/-) corneas is compromised and suggested Pax6(+/-) corneas show the...

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Identifiers

PMID: 19933176
DOI: 10.1167/iovs.09-4023

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