Article

β-catenin-mediated activation of Wnt target genes utilizes a biomolecular condensate-dependent mechanism

2023-10-10

Abstract excerpt

The Wnt/β-catenin signaling pathway plays numerous, essential roles in animal development and tissue/stem cell maintenance. The activation of genes regulated by Wnt/β-catenin signaling requires the nuclear accumulation of β-catenin, a transcriptional co-activator. β-catenin is recruited to many Wnt-regulated enhancers through direct binding to T-cell factor/Lymphoid enhancer factor (TCF/LEF) family transcription f...

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Literature Corpus work: 86966128-0caf-5ff0-af1d-317b1e41a38e
DOI: 10.1101/2023.10.09.561634

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