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Trailer Hitch tunes condensate phase behavior and mRNA partitioning to regulate P-body homeostasis during <i>Drosophila melanogaster</i> oogenesis

2025-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Processing bodies (P-bodies) are cytoplasmic granules that regulate mRNA storage, repression, and decay, yet how their internal organization supports selective mRNA regulation remains poorly understood. Here, we show that the conserved LSm protein Trailer Hitch (Tral) is a key organizer of P-body architecture and function in the Drosophila melanogaster female germline. Using quantitative confoc...

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Identifiers and source

Literature Corpus work
77110a48-3eb1-5ba8-a189-6af227d0770d
DOI
10.1101/2025.06.18.660414
Open publication

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Trailer Hitch tunes condensate phase behavior and mRNA partitioning to regulate P-body homeostasis during <i>Drosophila melanogaster</i> oogenesisDOI 10.1101/2025.06.18.660414
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