Article

DiMeLo-seq: a long-read, single-molecule method for mapping protein-DNA interactions genome-wide

2021-07-07

Abstract excerpt

Molecular studies of genome regulation often rely on the ability to map where specific proteins interact with genomic DNA. Existing techniques for mapping protein-DNA interactions genome-wide rely on DNA amplification methods followed by sequencing with short reads, which dissociates joint binding information at neighboring sites, removes endogenous DNA methylation information, and precludes the ability to reliabl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab132605-07bb-513f-9887-751ad12321f3
DOI: 10.1101/2021.07.06.451383

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DiMeLo-seq: a long-read, single-molecule method for mapping protein-DNA interactions genome-wideDOI 10.1101/2021.07.06.451383Read

DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosisSemantic proximity Read

Long-range single-molecule mapping of chromatin modification in eukaryotesSemantic proximity Read

Fine Mapping Regulatory Variants by Characterizing Native CpG Methylation with Nanopore Long-Read SequencingSemantic proximity Read

Genome-wide epigenetic profiling of 5-hydroxymethylcytosine by long-read optical mappingSemantic proximity Read

Methylation-dependent and -independent genomic targeting principles of the MBD protein family.Semantic proximity Read

μDamID: a microfluidic approach for imaging and sequencing protein-DNA interactions in single cellsSemantic proximity Read

Single-cell mapping of regulatory DNA:Protein interactionsSemantic proximity Read

Genome-wide distribution of DNA methylation at single-nucleotide resolution.Semantic proximity Read

Characterizing cellular heterogeneity in chromatin state with scCUT&Tag-proSemantic proximity Read

Pash 3.0: A versatile software package for read mapping and integrative analysis of genomic and epigenomic variation using massively parallel DNA sequencing.Semantic proximity Read

A map of direct TF-DNA interactions in the human genomeSemantic proximity Read

Protein binding and methylation on looping chromatin accurately predict distal regulatory interactionsSemantic proximity Read