Article

The spreading of facultative H3K9me3-heterochromatin drives congenital disease

2023-08-14

Abstract excerpt

Heterochromatin marked by trimethylated histone 3 at lysine 9 (H3K9me3) plays fundamental roles in reprogramming to direct cell fate determination in higher eukaryotes. However, the upstream factors that guide the establishment and spreading of H3K9me3-heterochromatin, leading to human developmental malformations, remain elusive. In this study, we found that Cdk13, a member of RNA polymerase II (RNAPII) kinase, su...

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Literature Corpus work: ab106bf3-be0b-5bd2-a065-73a001893130
DOI: 10.1101/2023.08.11.552907

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