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Article

The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila.

Development (Cambridge, England) - 1 Jan 2006

Zhang Weiguo, Deng Huai, Bao Xiaomin, Lerach Stephanie, Girton Jack, Johansen Jørgen, Johansen Kristen M

Abstract excerpt

In this study, we show that a reduction in the levels of the JIL-1 histone H3S10 kinase results in the spreading of the major heterochromatin markers dimethyl H3K9 and HP1 to ectopic locations on the chromosome arms, with the most pronounced increase on the X chromosomes. Genetic interaction assa...

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Source

Identifiers

PMID: 16339185
DOI: 10.1242/dev.02199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16339185-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila.PMID 16339185Read ↗

Reduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase.Semantic proximity Read ↗

JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila.Semantic proximity Read ↗

The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila.Semantic proximity Read ↗

Domain requirements of the JIL-1 tandem kinase for histone H3 serine 10 phosphorylation and chromatin remodeling in vivo.Semantic proximity Read ↗

Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages.Semantic proximity Read ↗

A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila.Semantic proximity Read ↗

The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin.Semantic proximity Read ↗

The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes.Semantic proximity Read ↗

Histone modification and the control of heterochromatic gene silencing in Drosophila.Semantic proximity Read ↗

Functional antagonism between histone H3K4 demethylases in vivo.Semantic proximity Read ↗

Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster.Semantic proximity Read ↗

Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila.Semantic proximity Read ↗

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