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Article

Substitutions in the amino-terminal tail of neurospora histone H3 have varied effects on DNA methylation.

PLoS genetics - 1 Dec 2011

Adhvaryu Keyur K, Berge Emanuela, Tamaru Hisashi, Freitag Michael, Selker Eric U

Abstract excerpt

Eukaryotic genomes are partitioned into active and inactive domains called euchromatin and heterochromatin, respectively. In Neurospora crassa, heterochromatin formation requires methylation of histone H3 at lysine 9 (H3K9) by the SET domain protein DIM-5. Heterochromatin protein 1 (HP1) reads this mark and directly recruits the DNA methyltransferase, DIM-2. An ectopic H3 gene carrying a substitution at K9...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22242002
DOI: 10.1371/journal.pgen.1002423
PMCID: PMC3248561

Genes

SET

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