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Article

PWWP mutants of the transcriptional cofactor JASPer divert promoter and enhancer activities and suppress position effect variegation in Drosophila.

Genes & development - 3 Aug 2026

Atkinson Derek, Barucka Karolina, Jerabek Lisa, Cardamone Francesco, Zhan Yinxiu, Kolodziejczyk Lisa, Regnard Catherine, Iovino Nicola, Reuter Gunter, Jenuwein Thomas

Abstract excerpt

Su(var) genes regulate the formation and maintenance of heterochromatin in Drosophila melanogaster, yet how factors associated with active chromatin influence heterochromatin stability remains poorly understood. Through a new genetic Su(var) screen, we identified two strong suppressors of position effect variegation that remain epistatic to increased Su(var)3-9 dosage in the In(1)w m4h rearrangement. Both...

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PMID: 42463462
DOI: 10.1101/gad.353541.125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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