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Article

Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3.

Nature cell biology - 1 Sept 2010

Santenard Angèle, Ziegler-Birling Céline, Koch Marc, Tora Làszlò, Bannister Andrew J, Torres-Padilla Maria-Elena

Abstract excerpt

In mammals, oocyte fertilization by sperm initiates development. This is followed by epigenetic reprogramming of both parental genomes, which involves the de novo establishment of chromatin domains. In the mouse embryo, methylation of histone H3 establishes an epigenetic asymmetry and is predominant in the maternal pronucleus. However, the roles of differential incorporation of histone H3 variants in the parental...

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Identifiers

PMID: 20676102
DOI: 10.1038/ncb2089
PMCID: PMC3701880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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