Article

ATP Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance And Is Depressed in Human Heart Failure

2024-06-10

Abstract excerpt

<h4>Background</h4> ATP-citrate lyase (ACLY) converts citrate into acetyl-CoA and oxaloacetate in the cytosol. It plays a prominent role in lipogenesis and fat accumulation coupled to excess glucose, and its inhibition is approved for treating hyperlipidemia. In RNAseq analysis of human failing myocardium, we found ACLY gene expression is reduced; however the impact this might have on cardiac function and/or met...

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Literature Corpus work: aaed6ad3-e433-572e-bce5-3796cf736a4c
DOI: 10.1101/2024.06.09.598152

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