Article

Succinyl-CoA-based energy metabolism dysfunctions in chronic heart failure

2021-12-07

Abstract excerpt

<title>Abstract</title> <p>Heart failure (HF) is a leading cause of death and repeated hospitalizations1. HF progression generally involves mitochondrial dysfunction2-4. However, how mitochondria react to chronic HF remains unclear. Here, we show the molecular basis of mitochondrial dysfunction in chronic HF, which is characterized by altered succinyl-CoA metabolism. In myocardial mitochondria of coronary ligated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4759b392-349d-51e3-8495-17ab944d021f
DOI: 10.21203/rs.3.rs-838227/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Succinyl-CoA-based energy metabolism dysfunctions in chronic heart failureDOI 10.21203/rs.3.rs-838227/v1Read

Mitochondrial Distress Signals at the Heart-Liver Interface: Molecular Links Between MASLD and Heart FailureSemantic proximity Read

Shexiang baoxin pill protects against myocardial infarction induced chronic heart failure by activating energy metabolism via modulating mitochondrial biogenesisSemantic proximity Read

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.Semantic proximity Read

Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.Semantic proximity Read

Murine metabolic HFpEF is associated with mitochondrial substrate inflexibility and S-nitrosylation remodelingSemantic proximity Read

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromesSemantic proximity Read

Myocardial substrate metabolism in the normal and failing heart.Semantic proximity Read

Succinylation participates in the progress of Idiopathic pulmonary fibrosis through mitochondrial energy metabolismSemantic proximity Read

ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the HeartSemantic proximity Read

13C‐breath tests for clinical investigation of liver mitochondrial functionSemantic proximity Read

ATP Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance And Is Depressed in Human Heart FailureSemantic proximity Read

Molecular Consequences of Pathogenic SDHA Variants: From Defective Flavinylation and Assembly to Lipid RemodelingSemantic proximity Read