Article

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

2024-05-07

Abstract excerpt

<h4>Background and aims</h4> Metabolic reprogramming represents as a pivotal hallmark for cancer, but TCA cycle in tumorigenesis and progression has long been neglected. Solute carrier (SLC) transporters mediate the transport of TCA cycle intermediates across membrane, but their functions in cancer pathogenesis remains unclear. <h4>Approaches & Results</h4> Using integrated analysis of solute carrier (SLC) trans...

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Literature Corpus work: d99eb70a-c8be-5088-92e8-0717dc2b1b92
DOI: 10.1101/2024.05.04.591017

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