Article

Reductive carboxylation via isocitrate dehydrogenase 1 supports cardiac metabolic adaptation during oncometabolic stress

2026-06-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cardiovascular disease and cancer are the two leading causes of morbidity and mortality worldwide. Metabolic dysregulation of cancer cells extends beyond the tumor microenvironment and increases the risk for cardiovascular diseases. One common somatic mutation in cancer cells affects isocitrate dehydrogenase (IDH) 1 and 2, which catalyzes the oxidative decarboxylation of iso...

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Literature Corpus work: 3858b19e-29de-53a1-aac0-97b1f381bb63
DOI: 10.64898/2026.06.06.727699

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