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Article

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2016

Karlstaedt Anja, Zhang Xiaotian, Vitrac Heidi, Harmancey Romain, Vasquez Hernan, Wang Jing Han, Goodell Margaret A, Taegtmeyer Heinrich

Abstract excerpt

Hematologic malignancies are frequently associated with cardiac pathologies. Mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a subset of acute myeloid leukemia patients, causing metabolic and epigenetic derangements. We have now discovered that altered metabolism in leukemic cells has a profound effect on cardiac metabolism. Combining mathematical modeling and in vivo as well as ex vivo studies,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27582470
DOI: 10.1073/pnas.1601650113
PMCID: PMC5027422

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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