Article

ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart

2024-06-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Metabolic remodeling is a hallmark of the failing heart. Oncometabolic stress during cancer increases the activity and abundance of the ATP-dependent citrate lyase (ACL, Acly ), which promotes histone acetylation and cardiac adaptation. ACL is critical for the de novo synthesis of lipids, but how these metabolic alterations contribute to cardiac structural and functional ch...

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Literature Corpus work: ae791cf7-e88c-5daf-baa0-77459db39f42
DOI: 10.1101/2024.06.21.600099

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