Article
Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.
Apoptosis : an international journal on programmed cell death - 29 May 2026
Chen Li, Yang Xin-Rui, Jiang Yan, Cheng Shi-Qi, Wan Zhen-Xun, Wu Jin-Wen, Chen Ming-Tai, Li Yuan-Yuan, Luo Gang, Liu Meng-Nan
Abstract excerpt
Heart failure (HF) is a heterogeneous clinical syndrome characterized by phenotype-specific metabolic remodeling (e.g., ischemic vs. nonischemic, HF with HFrEF vs. HFpEF), with impaired metabolic flexibility serving as a central pathophysiological link. The physiological basis of normal cardiac metabolic flexibility is outlined, and the temporal trajectories and molecular mechanisms of metabolic remodeling across...
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