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Article

Acute arrhythmias in a long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency mouse model.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2026

Elizondo Gabriela, Scalco Arianna, Asal Ayah, Chung Hak, Gaston Garen, Habecker Beth A, Gillingham Melanie B

Abstract excerpt

Patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD), a mitochondrial fatty acid oxidation (FAO) disorder, frequently present with cardiomyopathy and can suffer from life-threatening arrhythmias and heart failure. Although these remain the leading causes of death, the pathophysiology remains unknown. We used an LCHADD mouse model to examine the mechanisms of impaired cardiac function. We...

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Share to 3-Hydroxyacyl CoA Dehydrogenases
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cardiomyopathies

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Share to Lipid Metabolism, Inborn Errors

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Identifiers

PMID: 41467851
DOI: 10.1152/ajpheart.00493.2025
PMCID: PMC12897990

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