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Article

Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements.

Communications biology - 14 Aug 2020

Rugema Ngango Y, Garland-Kuntz Elisabeth E, Sieng Monita, Muralidharan Kaushik, Van Camp Michelle M, O'Neill Hannah, Mbongo William, Selvia Arielle F, Marti Andrea T, Everly Amanda, McKenzie Emmanda, Lyon Angeline M

Abstract excerpt

Phospholipase Cε (PLCε) generates lipid-derived second messengers at the plasma and perinuclear membranes in the cardiovascular system. It is activated in response to a wide variety of signals, such as those conveyed by Rap1A and Ras, through a mechanism that involves its C-terminal Ras association (RA) domains (RA1 and RA2). However, the complexity and size of PLCε has hindered its structural and functional...

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Identifiers

PMID: 32796910
DOI: 10.1038/s42003-020-01178-8
PMCID: PMC7427993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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