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Article

Ryanodine receptors: structure and function.

The Journal of biological chemistry - 14 Sept 2012

Van Petegem Filip

Abstract excerpt

Ryanodine receptors (RyRs) are huge ion channels that are responsible for the release of Ca(2+) from the sarco/endoplasmic reticulum. RyRs form homotetramers with a mushroom-like shape, consisting of a large cytoplasmic head and transmembrane stalk. Ca(2+) is a major physiological ligand that triggers opening of RyRs, but a plethora of modulatory proteins and small molecules in the cytoplasm and sarco/endoplasmic...

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Identifiers

PMID: 22822064
DOI: 10.1074/jbc.R112.349068
PMCID: PMC3442496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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