Article

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

2020-04-05

Abstract excerpt

<h4>Summary</h4> Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell mediated immunity. Through a bioinformatics-led cell biological screen, we have identified Orai1 as a substrate for the rhomboid intramembrane protease, RHBDL2. We show that RHBDL2 preve...

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Literature Corpus work: d458c57c-aa7c-5d23-9dc5-35b00171c157
DOI: 10.1101/2020.04.04.025262

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