Article
Calcium as a molecular switch that regulates Annexin A11 N- and C-terminal domains interaction and its role in ALS.
International journal of biological macromolecules - 1 Apr 2026
Di Napoli Giulia, Alfurno Lorenzo, Fissore Alex, Raccuia Eleonora, Olivieri Paolo, Marengo Mauro, Oliaro-Bosso Simonetta, Piaz Fabrizio Dal, Catucci Gianluca, Gilardi Gianfranco, Velazquez-Campoy Adrian, Prischi Filippo, De Simone Angela, Spyrakis Francesca, Di Palma Francesco, Adinolfi Salvatore
Abstract excerpt
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive motor neuron loss, leading to muscle paralysis and respiratory failure. Genetic mutations, notably in the ANXA11 gene, have been implicated in both familial and sporadic ALS forms. ANXA11 functions as a cellular "tether," orchestrating the transport of RNA-protein complexes and lysosomes through its N-terminal (Nt) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.