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Article

Unveiling the role of iPLA2β in neurodegeneration: From molecular mechanisms to advanced therapies.

Pharmacological research - 1 Apr 2024

Liu Jiabin, Tan Jieqiong, Tang Beisha, Guo Jifeng

Abstract excerpt

Calcium-independent phospholipase A2β (iPLA2β), a member of the phospholipase A2 (PLA2s) superfamily, is encoded by the PLA2G6 gene. Mutations in the PLA2G6 gene have been identified as the primary cause of infantile neuroaxonal dystrophy (INAD) and, less commonly, as a contributor to Parkinson's disease (PD). Recent studies have revealed that iPLA2β deficiency leads to neuroinflammation, iron accumulation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38395207
DOI: 10.1016/j.phrs.2024.107114

Genes

PLA2G6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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