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Article

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.

EBioMedicine - 1 Jan 2020

Liu Yang, Bunney Tom D, Khosa Sakshi, Macé Kévin, Beckenbauer Katharina, Askwith Trevor, Maslen Sarah, Stubbs Christopher, de Oliveira Taiana M, Sader Kasim, Skehel Mark, Gavin Anne-Claude, Phillips Christopher, Katan Matilda

Abstract excerpt

BACKGROUND: PLCγ enzymes are key nodes in cellular signal transduction and their mutated and rare variants have been recently implicated in development of a range of diseases with unmet need including cancer, complex immune disorders, inflammation and neurodegenerative diseases. However, molecular nature of activation and the impact and dysregulation mechanisms by mutations, remain unclear; both are critically...

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Identifiers

PMID: 31918402
DOI: 10.1016/j.ebiom.2019.102607
PMCID: PMC7000336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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