Article

MLL3/MLL4 enzymatic activity shapes DNA replication timing

2023-12-08

Abstract excerpt

<h4>SUMMARY</h4> Mammalian genomes are replicated in a precise order during S phase, which is cell-type-specific 1–3 and correlates with local transcriptional activity 2,4–8 , chromatin modifications 9 and chromatin architecture 1,10,11,12 . However, the causal relationships between these features and the key regulators of DNA replication timing (RT) are largely unknown. Here, machine learning was applied to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a45dcf41-3247-5e52-97c0-df4846782ac0
DOI: 10.1101/2023.12.07.569680

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MLL3/MLL4 enzymatic activity shapes DNA replication timingDOI 10.1101/2023.12.07.569680Read

The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem CellsSemantic proximity Read

RT States: systematic annotation of the human genome using cell type-specific replication timing programsSemantic proximity Read

Concert: Genome-wide prediction of sequence elements that modulate DNA replication timingSemantic proximity Read

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read

Spatiotemporal DNA Methylome Dynamics of the Developing Mammalian FetusSemantic proximity Read

Repli-seq: genome-wide analysis of replication timing by next-generation sequencingSemantic proximity Read

H3K37me1 couples transcription with DNA replication origin selectionSemantic proximity Read

Replication Timing Networks: a novel class of gene regulatory networksSemantic proximity Read

MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cellsSemantic proximity Read

A Cell type-specific Class of Chromatin Loops Anchored at Large DNA Methylation NadirsSemantic proximity Read

Partially methylated domains are hallmarks of a cell specific epigenome topologySemantic proximity Read

Cell type- and chromosome-specific chromatin landscapes and DNA replication programs of <i>Drosophila</i> testis tumor stem cell-like cellsSemantic proximity Read