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Ethambutol resistance in <i>Mycobacterium avium-intracellulare</i> is associated with mutations in the <i>embA–embB</i> promoter and <i>embB</i>

2026-05-27

Abstract excerpt

Ethambutol (EMB) is a vital drug for treating Mycobacterium avium-intracellulare (MAI) infections; however, the genomic mutations underlying EMB resistance in MAI remain unclear. Herein, we evaluated eight sets of MAI clinical isolates, each containing at least two serial isolates collected from the same patient who received EMB in Japan. In four sets, the isolates independently increased EMB MIC by 4-fold, coinc...

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Literature Corpus work
aa580ac9-cc18-5277-9519-68fff97594e2
DOI
10.64898/2026.05.23.727351
Open publication

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