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mbtD and celA1 association with ethambutol resistance in Mycobacterium tuberculosis: A multiomics analysis

31 Aug 2022

Abstract excerpt

Ethambutol (EMB) is a first-line antituberculosis drug currently being used clinically to treat tuberculosis. Mutations in the embCAB operon are responsible for EMB resistance. However, the discrepancies between genotypic and phenotypic EMB resistance have attracted much attention. We induced EMB resistance in Mycobacterium tuberculosis in vitro and used an integrated genome–methylome–transcriptome–proteome...

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PMID: 36118032
DOI: 10.3389/fcimb.2022.959911

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