Article
Nucleotide polymorphism associated with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis.
Current microbiology - 1 Nov 2006
Srivastava S, Garg A, Ayyagari A, Nyati K K, Dhole T N, Dwivedi S K
Abstract excerpt
Ethambutol (EMB) is a first-line drug used for antitubercular therapy in combination with other drugs as recommended by World Health Organization DOTS/DOTS-Plus regimens. EMB is also effective in the treatment of opportunistic mycobacterial infections in patients with human immunodeficiency virus. The emb locus has been considered as a drug target for EMB, and substitutions of codon 306 in Mycobacterium...
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